Roy NeillDirector
Basil RathboneSherlock Holmes
Nigel BruceDr. John H. Watson
Lionel AtwillProf. Moriarty
Kaaren VerneCharlotte Eberli
William Post Jr.Dr. Franz Tobel
Dennis HoeyInspector Lestrade
Mary GordonMrs. Hudson
Holmes HerbertSir Reginald Bailey
Henry VictorProfessor Frederick Hoffner (uncredited)
Paul FixMueller (uncredited)
Rudolph AndersBraun (uncredited)
Harold De BeckerPeg Leg (uncredited)
Harry CordingJack Brady (uncredited)
Harry WoodsKurt (uncredited)
George Burr MacannanGottfried (uncredited)
Paul BryarSwiss waiter (uncredited)
Vicki CampbellFemale RAF pilot (uncredited)
Guy KingsfordFoot patrolman (uncredited)
James CravenRAF officer watching bombsight test (uncredited)
George EldredgePoliceman outside Durer's (uncredited)
Michael MarkGeorge (uncredited)